Short-term zinc supplementation in middle-aged runners

Authors

DOI:

https://doi.org/10.62827/nb.v23i4.3038

Keywords:

Nutrition in sport; zinc; testosterone; track and field.

Abstract

Introduction: Middle-aged runners often use supplements to enhance performance and ensure health. In this context, zinc supplementation is associated with increased testosterone levels, although the literature on the subject presents inconclusive results. Objective: To investigate the short-term effect of zinc supplementation on free testosterone levels and anthropometric parameters in middle-aged male runners. Methods: Ten long-distance runners were selected. The protocol was divided into three stages: initial assessment, supplementation, and final assessment. Evaluations included dietary recall, anthropometric measurements, maximal oxygen consumption, and a saliva sample to measure free testosterone concentration. All runners ingested a capsule containing 50 mg/day of chelated zinc (once daily for 15 days). Results: The sample consisted of middle-aged runners (55.5 ± 4.8 years) with good cardiorespiratory fitness (46.9 ± 4.8 ml.kg⁻¹.min⁻¹) and body mass index (BMI) values indicative of overweight (25.6 ± 2.1 kg/m²). Testosterone levels were adequate (74.2 ± 46.5 pg/ml); however, six runners had values below the diagnostic threshold (70 pg/ml). Conclusion: Our study did not observe any difference in free testosterone concentrations after 15 days of zinc supplementation. We noted a caloric intake lower than energy expenditure, low consumption of carbohydrates, proteins, iron, and potassium, along with higher intake of sodium and cholesterol.

Author Biographies

  • Marcos Cibelli Castiel , IPA

    Graduado em Nutrição, Centro Universitário Metodista (IPA), Porto Alegre, RS, Brasil

  • Douglas Luis da Silva Nitzke , CESUCA

    Graduado em Nutrição, Cesuca Centro Universitário (CESUCA), Cachoeirinha, RS, Brasil

  • Ethiane Vieira Verdeco , IPA

    Graduada em Nutrição, Centro Universitário Metodista (IPA), Porto Alegre, RS, Brasil

  • Bruno Costa Teixeira , UEMG

    Departamento de Ciências do Movimento Humano (DCHM), Faculdade de Educação Física, Universidade do Estado de Minas Gerais (UEMG), Ibirité, MG, Brasil

  • André Pontes-Silva , UFSCAR

    Programa de Pós-Graduação em Fisioterapia, Departamento de Fisioterapia, Universidade Federal de São Carlos (UFSCAR), São Carlos, SP, Brasil

  • Gustavo dos Santos Ribeiro , UFCSPA

    Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil

  • André Luiz Lopes , UFRGS

    Programa de Pós-Graduação em Ciências do Movimento Humano, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil

  • Randhall Bruce Kreismann Carteri, UFRGS

    Programa de Pós-Graduação em Hepatologia, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil

References

Rojo J, Rocha F. Análise do perfil dos corredores e eventos de corridas de rua da cidade de Curitiba-PR. Educación Física y Ciencia 2018;20(4):15-16.

Andersen J. The State of Running 2019. Run Repeat, 2023. Disponível em: https://runrepeat.com/state-of-running (acesso em 09/09/2023).

Orwoll E, Lambert L, Marshall L, Phipps K, et al. Testosterone and estradiol among oldermen. J Clin Endocrinol Metab 2006; 91(4):1336-1344.

Vermeulen A, Kaufman J, Giagulli V. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996; 81(5):1821-1826.

Urban R, Bodenburg Y, Gilkison C, Foxworth, et al. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 1995; 269(5):E820-E826.

Anderson K, Rosner W, Khan M, New M, et al. Diet-hormone interactions: protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci 1987; 40(18):1761-1768.

Venkatraman J, Pendergast D. Effect of dietary intake on immune function in athletes. Sports Med 2002; 32(5):323-337.

Hisasue S. Contemporary perspective and management of testosterone deficiency: Modifiable factors and variable management. International journal of urology : official journal of the Japanese Urological Association 2015; 22(12), 1084–1095.

Schoofs H, Schmit J, Rink L. Zinc Toxicity: Understanding the Limits. Molecules 2024; 29(13):3130.

Te L, Liu J, Ma J, Wang S. Correlation between serum zinc and testosterone: A systematic review. J Trace Elem Med Biol. 2023;76:127124.

Santos H, Teixeira F. Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism. Aging Male 2019; 23(5):669-678.

Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8. doi: 10.1016/s0899-9007(96)80058-x. PMID: 8875519.

Marfell-Jones M, Olds T, Stewart A, Carter J. International Standards for Anthropometric Assessment. Potchefstroom: Northwest University; 2006.

Petroski E, Pires-Neto C. Validação de equações antropométricas para a estimativa dadensidade corporal em homens. Rev Bras Ativ 1996; 1(3):5-14.

Fisberg R, Marchioni D, Colucci, A. Avaliação do consumo alimentar e da ingestão de nutrientesna prática clínica. Arq Bras Endocrinol Metabol 2009; 53(5):617-624.

NEPA – NÚCLEO DE ESTUDOS E PESQUISAS EM ALIMENTAÇÃO. Tabela Brasileira de Composição de Alimentos (TACO) 1ª ed. Campinas: NEPA – UNICAMP, 2004. 42 p.

Tabela Brasileira de Composição de Alimentos (TBCA). Universidade de São Paulo (USP). Food Research Center (FoRC). Versão 7.2. São Paulo, 2023. Disponível em: http://www.fcf.usp.br/tbca.

Institute of Medicine (US) Subcommittee on Interpretation and Uses of Dietary Reference Intakes, & Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (2000). DRI Dietary Reference Intakes: Applications in Dietary Assessment. National Academies Press (US).

Cunningham J. A reanalysis of the factors influencing basal metabolic rate in normal adults. Am J Clin Nutr 1980; 33(11):2372-2374.

Koutlianos N, Dimitros E, Metaxas T, Cansiz M, et al. Indirect estimation of VO2max in athletes by ACSM's equation: valid or not? Hippokratia 2013; 17(2):136-40.

Dave S, Fisher M. Relative energy deficiency in sport (RED - S). Curr Probl Pediatr Adolesc Health Care 2022;52(8):101242.

Kerksick, C.M., Wilborn, C.D., Roberts, M.D. et al. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr 2018; 15(1):38.

Thomas DT, Erdman KA, Burke LM. American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance. Med Sci Sports Exerc. 2016 Mar;48(3):543-68.

Hyde Z, Flicker L, Almeida O, Hankey G, et al. Low free testosterone predicts frailty in older men: the health in men study. J Clin Endocrinol Metabol 2010; 95(7);3165-3172.

Tipton KD. Efficacy and consequences of very-high-protein diets for athletes and exercisers. Proc Nutr Soc. 2011 May;70(2):205-14.

Creighton BC, Hyde PN, Maresh CM, Kraemer WJ, Phinney SD, Volek JS. Paradox of hypercholesterolaemia in highly trained, keto-adapted athletes. BMJ Open Sport Exerc Med 2018; 4(1):e000429.

Bui, S., Oliver, J., Mardock, M., Beihl, A. and Riechman, S.E. High Egg Cholesterol Consumption May Not Affect Blood Serum Cholesterol Levels in Elite Athletes in Training. FASEB J 2010, 24: 628.6-628.6.

Gomes, G.K., de Branco, F.M.S., Santos, H.O. et al. Cholesterol intake and serum total cholesterol levels are not associated with total testosterone levels in men: a cross-sectional study from NHANES 2013–2014. Lipids Health Dis 2023; 22(1):168.

Bagatell C, Knopp R, Rivier J, et al. Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels. Ann Intern Med 1992; 116(12):967-973.

Koury J, Donangelo C. Zinco, estresse oxidativo e atividade física. Rev Nutr 2003; 16(4):433-441.

Jungwirth A, Diemer T, Dohle G, Giwerman A, et al. Diretrizes para o diagnóstico e tratamento da infertilidade masculina. Sociedade Brasileira de Urologia 2012

Kilic M, Baltaci A, Gunay M, Gökbel H, et al. The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc. Neuro Endocrinol Lett 2006; 27(1-2):247-252.

Neek L, Gaeini A, Choobineh S. Effect of Zinc and Selenium Supplementation on Serum Testosterone and Plasma Lactate in Cyclist After an Exhaustive Exercise Bout. Biol Trace Elem Res 2011; 144(1-3):454-462

Koehler, K., Parr, M., Geyer, H. et al. Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement. Eur J Clin Nutr 2009; 63(1):65-70.

Published

2024-11-16

Issue

Section

Artigos originais

How to Cite

Short-term zinc supplementation in middle-aged runners. (2024). Nutrição Brasil, 23(4), 1062-1072. https://doi.org/10.62827/nb.v23i4.3038