Avaliação radiográfica dos efeitos da dieta hiperlipídica no osso mandibular em animais
DOI:
https://doi.org/10.62827/nb.v23i4.3034Palavras-chave:
Osso; Dieta hiperlipídica; Mandíbula.Resumo
Introdução: Considerando a fisiopatologia da periodontite apical (PA), uma doença inflamatória caracterizada pela reabsorção óssea, é provável que as alterações ósseas promovidas pela dieta hiperlipídica (DH) também sejam capazes de influenciar o mecanismo de desenvolvimento das lesões de PA. Objetivo: Avaliar através de radiografia periapical os principais efeitos da dieta hiperlipídica no osso mandibular em modelos animais. Métodos: Foram utilizados ratos Wistar (n=16), isogênicos, com 8 semanas de idade. Metade dos animais foi submetida à DH e a outra metade à dieta normal (C). Após 8 semanas, foi estimulado o desenvolvimento de lesão perirradicular (LP) nos primeiros molares inferiores esquerdos através da exposição pulpar. Após 40 dias, os animais foram eutanasiados. O sangue foi coletado para a realização da análise bioquímica (colesterol total, HDL, VLDL e triglicerídeos séricos) e mandíbula para análise radiográfica (espaço do ligamento periodontal, diâmetro do côndilo e espessura mandibular). Resultados: A DH promoveu aumento significativo nas concentrações séricas de triglicerídeos (p<0.05) e VLDL (p<0.05) no grupo DH. Os animais do grupo DH apresentaram redução tanto no diâmetro do côndilo (p<0.05) como na espessura mandibular (p<0.05), e aumento no espaço do ligamento periodontal (p<0.05) quando comparados ao grupo C. Conclusão: A DH provocou alterações significativas no osso mandibular, influenciando inclusive na resposta perirradicular à infecção endodôntica.
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Copyright (c) 2024 Karina Mara Martins da Costa Pinto, Vitor Mendes da Encarnação, Denise Gonçalves Pinho Dantas, Moisés João de Oliveira , Camila Stofela Sodré, Marco Orsini, Carlos Alberto Santos Costa, Rachel Moreira Morais dos Santos, Sabrina de Castro Brasil, Luciana Armada (Autor)
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