Impact of early mobilization on functional outcomes after ischemic stroke
DOI:
https://doi.org/10.62827/fb.v27i6.1227Keywords:
Ischemic Stroke; Early Mobilization; Neurological Rehabilitation; Functional Status; Outcome Assessment.Abstract
Introduction: Ischemic stroke is one of the leading causes of mortality and functional disability worldwide. Early mobilization is used in the rehabilitation of these patients to enhance neurological recovery and reduce complications associated with prolonged immobility; however, there remains disagreement regarding the optimal timing and intensity of these interventions. The objective of this study is to understand the benefits of early mobilization, the most appropriate time to begin it, and its impact on functional independence over time. Methods: This is a systematic review with a meta-analysis. Searches were conducted in the PubMed/MEDLINE (Medical Literature Analysis and Retrieval System Online), Cochrane Library, EBSCOhost, and SciELO (Scientific Electronic Library Online) databases; seven studies were included, totaling 782 participants. Results: Early mobilization was shown to be associated with better functional outcomes when initiated between 24 and 48 hours after an ischemic stroke. Protocols initiated within less than 24 hours yielded less favorable results. Improvements were also observed in balance, functional ability, and a reduction in complications related to immobility, including venous thromboembolism, pressure ulcers, and pneumonia. In elderly patients, structured early mobilization protocols demonstrated additional clinical and functional benefits. Conclusion: Early mobilization has proven to be a safe and effective strategy for patients with acute ischemic stroke, especially when initiated between 24 and 48 hours after the event. The intervention contributes to greater functional independence and a lower incidence of complications associated with immobility. However, further studies are needed to more precisely define the optimal time window and the appropriate intensity of early interventions.
References
Mao YX, Zhang Y, Wen YH, Hu C. Effects of evidence-based early mobilization on prognostic outcomes in older patients with acute ischemic stroke. Front Public Health. 2026; 14:1774045. doi:10.3389/fpubh.2026.1774045.
Poletto SR, Rebello LC, Valença MJM, Rossato D, Almeida AG, Brondani R, et al. Early mobilization in ischemic stroke: a pilot randomized trial of safety and feasibility in a public hospital in Brazil. Cerebrovasc Dis Extra. 2015;5(1):31-40. doi:10.1159/000381417.
Yen HC, Pan GS, Jeng JS, Chen WS. Impact of early mobilization on patients with acute ischemic stroke treated with thrombolysis or thrombectomy: a randomized controlled trial. Neurorehabil Neural Repair. 2024;38(5):339-349. doi:10.1177/15459683241236443.
Ademoyegun AB, Awotidebe TO, Odetunde MO, Inaolaji SO, Bakare SO, Azeez FW, et al. Effects of very early exercise on inflammatory markers and clinical outcomes in patients with ischaemic stroke: a randomized controlled trial. BMC Neurol. 2025; 25:121. doi:10.1186/s12883-025-04132-5.
Wang F, Zhang S, Zhou F, Zhao M, Zhao H. Early physical rehabilitation therapy between 24 and 48 h following acute ischemic stroke onset: a randomized controlled trial. Disabil Rehabil. 2021;45(1):1-8. doi:10.1080/09638288.2021.1897168.
Wang J, Li Y, Qi L, Mamtilahun M, Liu C, Liu Z, et al. Advanced rehabilitation in ischaemic stroke research. Stroke Vasc Neurol. 2024;9:e002285. doi:10.1136/svn-2022-002285.
Zhang X, Li H, Gu Y, Ping A, Chen J, Zhang Q, et al. Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery. Nat Commun. 2025;16:3089. doi:10.1038/s41467-025-58254-y.
Rahayu UB, Wibowo S, Setyopranoto I. The effectiveness of early mobilization time on balance and functional ability after ischemic stroke. Open Access Maced J Med Sci. 2019;7(7):1088-1092. doi:10.3889/oamjms.2019.269.
Tong Y, Cheng Z, Rajah GB, Duan H, Cai L, Zhang N, et al. High intensity physical rehabilitation later than 24 h post stroke is beneficial in patients: a pilot randomized controlled trial study in mild to moderate ischemic stroke. Front Neurol. 2019; 10:113. doi:10.3389/fneur.2019.00113.
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Copyright (c) 2026 Ana Carolina Furio da Cunha, Caroline de Faria, Cecília Abreu Gonçalves, Rafael Endringer Gava, Maria Cecília Ataíde Gomes (Autor)

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