Impacto das doenças sistêmicas na mecânica respiratória avaliada pela oscilometria de impulso: Uma revisão integrativa

Autores

DOI:

https://doi.org/10.62827/fb.v27i4.1200

Palavras-chave:

Oscilometria; Mecânica Respiratória; Obesidade; Síndrome Metabólica; Hipertensão Arterial Sistêmica.

Resumo

Introduction: Systemic diseases that are not primarily pulmonary may affect respiratory mechanics through inflammatory, metabolic, vascular, and mechanical mechanisms, producing functional abnormalities that are not always identified by conventional methods. Objective: To analyze the evidence on the impact of non-respiratory systemic diseases on respiratory mechanics in adults assessed by impulse oscillometry. Methods: This was an integrative literature review, conducted based on a guiding question developed according to population, interest, and context. The search was performed in PubMed, Scientific Electronic Library Online (SciELO), and Latin American and Caribbean Health Sciences Literature (LILACS), considering original studies published in the last fifteen years, in Portuguese, English, or Spanish, with full text available. Studies involving adults with systemic diseases that are not primarily pulmonary, in which respiratory mechanics were assessed by impulse oscillometry, were included. Study selection was performed by title and abstract screening, followed by full-text assessment. Data were extracted and synthesized descriptively. Results: A total of 117 records were identified, of which ten studies composed the final sample. Observational studies predominated, with a greater concentration on obesity and excess weight, in addition to metabolic syndrome, systemic arterial hypertension, pulmonary arterial hypertension, systemic sclerosis, and hepatic steatosis. The findings showed a predominance of resistive abnormalities, accompanied by signs of ventilatory heterogeneity and possible distal involvement, including individuals with preserved spirometry. Conclusion: Non-pulmonary systemic diseases may affect respiratory mechanics in adults, and impulse oscillometry constitutes a sensitive complementary tool for detecting subclinical functional alterations in respiratory mechanics.

Biografia do Autor

  • Stevan Frederico Leonetti Peres , UNIFESP

    Federal University of São Paulo (UNIFESP), Institute of Science and Technology, São José dos Campos, SP, Brazil

  • Eugênia Casella Tavares de Mattos , UNIFESP

    Federal University of São Paulo (UNIFESP), Institute of Science and Technology, São José dos Campos, SP, Brazil

  • Fabio Gava Aoki , UNIFESP

    Federal University of São Paulo (UNIFESP), Institute of Science and Technology, São José dos Campos, SP, Brazil

Referências

World Health Organization. Noncommunicable diseases 2025. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases (accessed March 18, 2026).

Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev Respir Med 2018;12:755–67. https://doi.org/10.1080/17476348.2018.1506331.

King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellacà RL, et al. Technical standards for respiratory oscillometry. Eur Respir J 2020;55. https://doi.org/10.1183/13993003.00753-2019.

Kaminsky DA, Simpson SJ, Berger KI, Calverley P, de Melo PL, Dandurand R, et al. Clinical significance and applications of oscillometry. Eur Respir Rev 2022;31. https://doi.org/10.1183/16000617.0208-2021.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021:n71. https://doi.org/10.1136/bmj.n71.

Oppenheimer BW, MacHt R, Goldring RM, Stabile A, Berger KI, Parikh M. Distal airway dysfunction in obese subjects corrects after bariatric surgery. Surgery for Obesity and Related Diseases 2012;8:582–9. https://doi.org/10.1016/j.soard.2011.08.004.

Oppenheimer BW, Berger KI, Segal LN, Stabile A, Coles KD, Parikh M, et al. Airway dysfunction in obesity: Response to voluntary restoration of end expiratory lung volume. PLoS One 2014;9. https://doi.org/10.1371/journal.pone.0088015.

Albuquerque CG de, Andrade FMD de, Rocha MA de A, Oliveira AFF de, Ladosky W, Victor EG, et al. Determining respiratory system resistance and reactance by impulse oscillometry in obese individuals. Jornal Brasileiro de Pneumologia 2015;41:422–6. https://doi.org/10.1590/S1806-37132015000004517.

van de Kant KDG, Paredi P, Meah S, Kalsi HS, Barnes PJ, Usmani OS. The effect of body weight on distal airway function and airway inflammation. Obes Res Clin Pract 2016;10:564–73. https://doi.org/10.1016/j.orcp.2015.10.005.

de Sant’Anna M, Carvalhal RF, de Oliveira F da FB, Zin WA, Lopes AJ, Lugon JR, et al. Respiratory mechanics of patients with morbid obesity. Jornal Brasileiro de Pneumologia 2019;45. https://doi.org/10.1590/1806-3713/e20180311.

Brandao-Rangel MAR, Moraes-Ferreira R, Oliveira-Junior MC, Santos-Dias A, Bachi ALL, Gabriela-Pereira G, et al. Pulmonary function changes in older adults with and without metabolic syndrome. Sci Rep 2021;11. https://doi.org/10.1038/s41598-021-96766-x.

Brandao-Rangel MAR, Brill B, de Souza Carvalho E, Melamed D, Moraes-Ferreira R, Silva-Reis A, et al. Physically Active Lifestyle Attenuates Impairments on Lung Function and Mechanics in Hypertensive Older Adults. Adv Respir Med 2024;92:278–90. https://doi.org/10.3390/arm92040027.

Xu J, Sun X, Cao Y, Zhu H, Yang W, Liu J, et al. Fractional exhaled nitric oxide in idiopathic pulmonary arterial hypertension and mixed connective tissue disease complicating pulmonary hypertension. BMC Pulm Med 2024;24. https://doi.org/10.1186/s12890-024-03004-x.

Bonifazi M, Sverzellati N, Negri E, Pomponio G, Seletti V, Bonini M, et al. Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. Rheumatology (United Kingdom) 2020;59:641–9. https://doi.org/10.1093/rheumatology/kez340.

Shen HC, Wang CH, Yang CW, Lin YH, Yeh HY, Perng DW, et al. Elevated neutrophil-to-lymphocyte ratio combined with decreased lymphocyte-to-monocyte ratio is associated with increased peripheral airway resistance in patients with hepatic steatosis. Medicine (United States) 2024;103:e38530. https://doi.org/10.1097/MD.0000000000038530.

Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol (1985) 2010;108:206–11. https://doi.org/10.1152/japplphysiol.00694.2009.

Baffi CW, Wood L, Winnica D, Strollo PJ, Gladwin MT, Que LG, et al. Metabolic Syndrome and the Lung. Chest 2016;149:1525–34. https://doi.org/10.1016/j.chest.2015.12.034.

Leone N, Courbon D, Thomas F, Bean K, Jégo B, Leynaert B, et al. Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. Am J Respir Crit Care Med 2009;179:509–16. https://doi.org/10.1164/rccm.200807-1195OC.

Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MC. The aging lung: Physiology, disease, and immunity. Cell 2021;184:1990–2019. https://doi.org/10.1016/j.cell.2021.03.005.

Baughman C, Gong Y, Wu Y, Hanlon E, Juraschek S. Nonpharmacologic Management of Hypertension in Older Adults. Clin Geriatr Med 2024;40:615–28. https://doi.org/10.1016/j.cger.2024.04.013.

Charchar FJ, Prestes PR, Mills C, Ching SM, Neupane D, Marques FZ, et al. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension. J Hypertens 2024;42:23–49. https://doi.org/10.1097/HJH.0000000000003563.

Manning EP, Mishall P, Ramachandra AB, Hassab AHM, Lamy J, Peters DC, et al. Stiffening of the human proximal pulmonary artery with increasing age. Physiol Rep 2024;12:e16090. https://doi.org/10.14814/phy2.16090.

Masugata H, Senda S, Okada H, Murao K, Inukai M, Himoto T, et al. Association between arterial stiffness and pulmonary function in hypertensive patients. Hypertens Res 2012;35:388–92. https://doi.org/10.1038/hr.2011.199.

Harrison DG, Coffman TM, Wilcox CS. Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circ Res 2021;128:847–63. https://doi.org/10.1161/CIRCRESAHA.121.318082.

Durante A, Mazzapicchi A, Baiardo Redaelli M. Systemic and Cardiac Microvascular Dysfunction in Hypertension. Int J Mol Sci 2024;25. https://doi.org/10.3390/ijms252413294.

Yokoyama YM, Watanabe R, Yamaguchi T, Ishihara R, Shiomi M, Fujita Y, et al. Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Current Therapeutic Strategies and Future Prospects. Biomolecules 2026;16. https://doi.org/10.3390/biom16010140.

Tettey A, Jiang Y, Li X, Li Y. Therapy for Pulmonary Arterial Hypertension: Glance on Nitric Oxide Pathway. Front Pharmacol 2021;12:767002. https://doi.org/10.3389/fphar.2021.767002.

Asano Y. The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies. J Clin Med 2020;9. https://doi.org/10.3390/jcm9092687.

Nihtyanova SI, Denton CP. Pathogenesis of systemic sclerosis associated interstitial lung disease. J Scleroderma Relat Disord 2020;5:6–16. https://doi.org/10.1177/2397198320903867.

Kumar R, Prakash S, Chhabra S, Singla V, Madan K, Gupta SD, et al. Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease. Indian J Med Res 2012;136:229–36.

Stefan N, Yki-Järvinen H, Neuschwander-Tetri BA. Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment. Lancet Diabetes Endocrinol 2025;13:134–48. https://doi.org/10.1016/S2213-8587(24)00318-8.

Miao L, Yang L, Guo L-S, Shi Q-Q, Zhou T-F, Chen Y, et al. Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease. J Clin Transl Hepatol 2022;10:230–7. https://doi.org/10.14218/JCTH.2021.00306.

Downloads

Publicado

2026-07-02

Como Citar

Impacto das doenças sistêmicas na mecânica respiratória avaliada pela oscilometria de impulso: Uma revisão integrativa. (2026). Fisioterapia Brasil, 27(4), 3703-3721. https://doi.org/10.62827/fb.v27i4.1200