Basic pulmonary function of Duchenne muscular dystrophy patients in a Brazilian sample
DOI:
https://doi.org/10.62827/fb.v26i1.1043Keywords:
Duchenne; Maximal Respiratory Pressures; Age Groups; Respiratory Function Tests; Child; Adolescent; Cross-Sectional Studies.Abstract
Introduction: Studies of lung and respiratory function favor the understanding of their variability and clinical applicability. Objective: Characterization and analysis of basic lung function (forced vital capacity – FVC, maximum respiratory pressures – MRP and peak cough flow – PFM) in a Brazilian sample of people with Duchenne muscular dystrophy (DMD) and development of predictive formulas. Methods: Sample of 231 medical records, divided into 2 groups: G1- 9 to 13 years and G2- 14 to 18 years. Descriptive analysis of the variables and Spearman correlation analysis were performed to verify association between them. Comparison of MRP by age used one-way ANOVA. Multiple regression analyses identified possible predictive variables for FVC and FVC (α=0.05). Results: Positive correlation between the variables studied and similarity with values in the literature. Analysis focusing on age showed Maximum Inspiratory Pressure (MIP) as a strong predictor of FVC. An equation was established to predict FVC from MRP and between MRP and PFM. Conclusion: The analysis of the age factor as an indicator of disease progression allowed the generation of predictive formulas for FVC from MIP and for PCF from MRP. It is noteworthy that MIP is a strong predictor of FVC.
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Copyright (c) 2025 Ana Cristina de Sousa Murray , Eneida Yuri Suda , Mariana Callil Voos , Renata Escorcio , Cynthia Bedeschi , Silvana Amando do Carmo , Fernando Alves Vale , Fátima Aparecida Caromano (Autor)
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