Liver transplantation Surgical aspects and evolution of the technique: A literature review

Authors

DOI:

https://doi.org/10.62827/fb.v26i5.1101

Keywords:

Liver Transplantation; General Surgery; Postoperative Care; Quality of Life; Physical Therapy Services.

Abstract

Introduction: Liver transplantation is a complex procedure indicated for patients with acute or chronic liver failure, whose success depends on appropriate donor and recipient selection, technical advancements, and multidisciplinary management. Objective: This study conducted a literature review on the surgical aspects and technical evolution of liver transplantation, emphasizing perioperative and postoperative care, complications, institutional protocols, impacts on patient survival and quality of life, and the importance of physiotherapy in functional rehabilitation and prevention of postoperative complications. Methods: A descriptive and analytical literature review was conducted, based on national and international publications available in the Virtual Health Library (BVS), PubMed (Public/Publisher MEDLINE), Latin American and Caribbean Literature in Health Sciences (LILACS), and the Virtual Health Library (BVS). Studies published between 2017 and 2025, in Portuguese, English, and Spanish, were included, encompassing reviews, descriptive studies, interventional studies, and institutional guidelines. Duplicate articles, isolated opinions, and interviews were excluded. Study selection was performed in three stages: identification, screening of titles and abstracts, and full-text reading of eligible studies. Results: Findings indicate that advanced surgical techniques, institutional protocols, intensive monitoring, and multidisciplinary care are crucial for graft preservation, morbidity reduction, and improved quality of life. Studies highlight the importance of standardized practices, waitlist management, infection prevention, and patient education to optimize clinical outcomes, as well as early physiotherapy intervention, including respiratory exercises, early mobilization, and functional training, which help reduce postoperative complications. Challenges include regional disparities in access, prolonged waiting times, and structural gaps in healthcare services. Conclusion: The success of liver transplantation depends on the integration of technical evolution, evidence-based protocols, multidisciplinary care, and continuous monitoring. Structured and individualized strategies, combined with patient education, implementation of postoperative physiotherapy protocols, and optimization of institutional resources, are essential to improve clinical outcomes, graft survival, and quality of life.

Author Biographies

  • Ian Miguel Freitas, EMESCAM

    Formado em Medicina pela Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória (EMESCAM), Vitória, ES, Brasil 

  • Áthila Silveira Santiago, UIT

    Formado em Medicina pela Universidade de Itaúna (UIT), Itaúna, MG, Brasil

  • Lucas Mesquita Ferreira , UIT

    Formado em Medicina pela Universidade de Itaúna (UIT), Itaúna, MG, Brasil

  • Marcelo Carlos da Silva Júnior , UIT

    Formado em Medicina pela Universidade de Itaúna (UIT), Itaúna, MG, Brasil

References

Associação Brasileira de Transplantes. Dimensionamento dos Transplantes no Brasil e em cada estado (2016–2023). Registro Brasileiro de Transplantes 2024 [Internet]. 2024 [cited 2025 Oct 6];30(4). Available from: https://site.abto.org.br/wp-content/uploads/2024/03/RBT_2023-Populacao_Atualizado.pdf

Siqueira LR, Siqueira LR, Mendes KDS, Galvão CM. Perfil epidemiológico e complicações de pacientes em fila de espera para transplante de fígado. BJT [Internet]. 2023 [cited 2025 Oct 6];26:e1923. Available from: https://doi.org/10.53855/bjt.v26i1.508_PT

Dias DM, Diogo D, Madaleno J, Tralhão JG. Critérios de seleção para transplantação hepática e modalidades terapêuticas como ponte na falência hepática aguda. BJT [Internet]. 2023 [cited 2025 Oct 6];26(1):e0823. Available from: https://doi.org/10.53855/bjt.v26i1.457_PORT

Gomes MO. O desempenho dos estados do Nordeste na realização do transplante hepático: 2015 a 2019 [Internet]. Salvador: Escola Bahiana de Medicina e Saúde Pública; 2022 [cited 2025 Oct 6]. Available from: https://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/6826

Furlan GF, Okamoto CT, Zini C, Peixoto IL. Transplante de fígado com órgãos de critérios expandidos e complicações relacionadas à internação. Rev Méd [Internet]. 2021 [cited 2025 Oct 6];79(2):73-5. Available from: https://doi.org/10.55684/79.2.1626

Vieira VPA, Cavalcante TMC, Leite MG, Diccini S. Sucesso do transplante hepático de acordo com o tempo em lista. Rev Enferm UFPE on line [Internet]. 2017 [cited 2025 Oct 6];11(7):2751-7. Available from: https://periodicos.ufpe.br/revistas/index.php/revistaenfermagem/article/view/23449

Grupo Integrado de Transplante de Fígado. Protocolo de transplante hepático [Internet]. HC–FMRP–USP; 2017 [cited 2025 Oct 6]. Available from: https://sites.usp.br/dcdrp/wp-content/uploads/sites/273/2017/05/protocolotx.pdf

Oliveira NDSP, Oliveira TM, dos Reis Corrêa A, Tiensoli SD, Bonisson PLV, de Lima Guimarães G, et al. Diagnósticos de enfermagem de pacientes pós-transplantados hepáticos em acompanhamento ambulatorial. Cogit Enferm [Internet]. 2019 [cited 2025 Oct 6];24:e59149. Available from: http://dx.doi.org/10.5380/ce.v24i0.59149

Albuquerque IVS, Simionato NAF, Bortolotto LA, Feltrim MIZ. Fisioterapia no paciente transplantado cardíaco com histoplasmose recente. Ciênc Med [Internet]. 2017 [cited 2025 Oct 6];27(1):1–7. Available from: https://seer.sis.puc-campinas.edu.br/cienciasmedicas/article/view/3799/2632

Perrier-Melo RJ, Figueira F, Guimarães GV, Costa MDC. High-intensity interval training in heart transplant recipients: a systematic review with meta-analysis. Arq Bras Cardiol [Internet]. 2018 [cited 2025 Oct 6];110(2):188–94. Available from: https://pubmed.ncbi.nlm.nih.gov/29466487/

Martins DS, Fontela PC, Padilha MLBA, Winkelmann ER. Análise físico funcional e cardiorrespiratória de pacientes em lista de espera para o transplante renal: estudo transversal. Rev Pesq Fisio [Internet]. 2018 [cited 2025 Oct 6];8(1):63–70. Available from: https://www5.bahiana.edu.br/index.php/fisioterapia/article/view/1753/2004

Kılıç L, Pehlivan E, Balcı A, Bakan ND. Effect of 8-week pulmonary rehabilitation program on dyspnea and functional capacity of patients on waiting list for lung transplantation. Turk Thorac J [Internet]. 2019 Mar 1 [cited 2025 Oct 6];21(2):110–5. Available from: https://pubmed.ncbi.nlm.nih.gov/32203001/

Stehlik J, Edwards LB, Kucheryavaya AY, Benden C, Dobbels F, Kirk R, et al. Ex-vivo heart perfusion: extending the limits of donor heart preservation. J Am Coll Cardiol [Internet]. 2019 [cited 2025 Oct 6];73(5):545–58. Available from: https://pubmed.ncbi.nlm.nih.gov/30697079/

Published

2025-10-20

How to Cite

Liver transplantation Surgical aspects and evolution of the technique: A literature review. (2025). Fisioterapia Brasil, 26(5), 2651-2661. https://doi.org/10.62827/fb.v26i5.1101