Rate of mechanical ventilation discontinuation in COVID-19 patients: a multicenter observational study

Authors

DOI:

https://doi.org/10.62827/fb.v25i5.1024

Keywords:

Respiration; airway extubation; intensive care units; COVID-19; physical therapy department.

Abstract

Introduction: The severe form of COVID-19 presents with severe inflammatory conditions and difficult-to-resolve respiratory failure, compatible with Acute Respiratory Distress Syndrome - ARDS. This condition requires the use of mechanical ventilation (MV) and is often difficult to wean. Objective: To determine the rate of discontinuation of mechanical ventilation (MV) in patients with COVID-19 treated in intensive care units of three hospitals in southern Brazil. Methods: Medical records of 270 patients with COVID-19 were reviewed to collect information on dates and parameters of MV, as well as health data prior to hospitalization. Length of ICU and MV stay, ICU mortality, use of positive end-expiratory pressure (PEEP) ≥ 10CmH2O, prone positioning, and hemodialysis were calculated. Results: Data from 258 patients were found, the majority of whom were male (56.20%), with a mean age of 62.31 ± 14.51 years. Hospitalizations lasted an average of 13.3 ± 10.12 days and MV was maintained for an average of 11.28 ± 8.91 days. The mortality rate found was 84.11% and 16.28% had successful MV discontinuation. Conclusion: After the institution of invasive ventilatory support, a small proportion of patients with COVID-19 survive without pressure support and the mortality rate is high.

Author Biographies

  • Lorena de Lima Oppelt, UFPel

    Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brasil

  • Stephanie Santana Pinto, UFPel

    Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brasil

  • Tauana Bandeira Gonçalves, UFPel

    Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brasil

  • Victoria Duquia da Silva, UCPEL

    Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brasil

  • Camilla Benigno Biana, HE-UFPel

    Hospital Escola da Universidade Federal de Pelotas (HE-UFPel), Pelotas, RS, Brasil

  • Rafael Bueno Orcy, UFPel

    Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brasil

References

Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the New York City Area. JAMA - Journal of the American Medical Association. 2020;323(20):2052–9.

Waterer GW, Rello J, Wunderink RG. COVID-19: First do no harm. Am J Respir Crit Care Med. 2020;201(11):1324–5.

Hasan SS, Capstick T, Ahmed R, Kow CS, Mazhar F, Merchant H a., et al. Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis. Expert Rev Respir Med. 2020;1–16.

Potere N, Valeriani E, Candeloro M, Tana M, Porreca E, Abbate A, et al. Acute complications and mortality in hospitalized patients with coronavirus disease 2019: A systematic review and meta-analysis. Crit Care. 2020;24(389):1–12.

Guzatti NG, Klein F, Oliveira JA, Rático GB, Cordeiro MF, Marmitt LP, et al. Predictive Factors of Extubation Failure in COVID-19 Mechanically Ventilated Patients. J Intensive Care Med. 1o de setembro de 2022;37(9):1250–5.

Ranzani OT, Bastos LSL, Gelli JGM, Marchesi JF, Baião F, Hamacher S, et al. Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data. Lancet Respir Med. 2021;2600(20):1–12.

Avendano CA, Parrish R, Lara JC, Rosenberg B, Camilo CSJ, Beattie J, et al. COMPLICATIONS OF PROLONGED MECHANICAL VENTILATION IN PATIENTS WITH COVID-19 INFECTION. Chest. outubro de 2023;164(4):A1804–5.

Deschamps FJ, Deschamps PS da S, Silva LC da, Blos EK, Savoldi ES, Garcia MJC, et al. Hospital cohort study on survival predictors for intubated coronavirus disease 2019 patients. Rev Assoc Med Bras. 2024;70(5).

De Souza Dos Santos G, Alves de Carvalho França de Macedo V, Oliniski Reikdal S, Graf ME, Mario Martin B, Joaquim Meier M. Ventilator-associated pneumonia risk factors in patients with severe COVID-19 in southern Brazil: A retrospective observational study. Infect Dis Health. 2024;

Goldwasser R, Augusto R:, Participantes F, Freitas EE, Saddy F, Amado V, et al. III Consenso Brasileiro de Ventilação Mecânica: Desmame e interrupção da ventilação mecânica. Vol. 33, J Bras Pneumol. 2007.

Barrasa H, Rello J, Tejada S, Martín A, Balziskueta G, Vinuesa C, et al. SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria. Anaesth Crit Care Pain Med. 2020;1–9.

Schneider B, Oliveira RA de, Friedman G, Moraes RB. Associação entre biomarcadores e sucesso do desmame ventilatório em pacientes com COVID-19: um estudo observacional. Critical Care Science. 2024;36.

Rodrigues M de S, Guimarães J, Cerqueira Filho RB de, Mota Júnior AA da, Moura JC de, Moura SM de. Perfil epidemiológico dos pacientes hospitalizados por COVID-19 em uma Unidade de Terapia Intensiva no interior do Brasil. Rev Med (Rio J). 8 de março de 2023;102(1).

Published

2024-11-29

How to Cite

Rate of mechanical ventilation discontinuation in COVID-19 patients: a multicenter observational study. (2024). Fisioterapia Brasil, 25(5), 1715-1724. https://doi.org/10.62827/fb.v25i5.1024